Enteral lactoferrin to prevent infection for very preterm infants: the ELFIN RCT

Grif­fiths et al, Health Tech­nol­o­gy Assess­ment,Decem­ber 2018 Abstract Back­ground Infec­tions acquired in hos­pi­tal are an impor­tant cause of mor­bid­i­ty and mor­tal­i­ty in very preterm infants. Sev­er­al small tri­als have sug­gest­ed that sup­ple­ment­ing the enter­al diet of very preterm infants with lacto­fer­rin, an antimi­cro­bial pro­tein processed from cow’s milk, pre­vents infec­tions…

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طفلى حديث الولادة و الصفراء

أ.د. أسامه عرفة إستشارى طب الأطفال وحديثى الولادة مستشفى بورفؤاد — بورسعيد يعتبر تغير لون جلد الطفل حديث الولادة إلى اللون الأصفر من الظواهر الشائعة جدا هذه الأيام ويصاحبها تساؤلات عديدة ولغط كثير من طرق العلاج والأسباب وخلاصة هذا الموضوع إن الأسباب العلمية حتى الآن غير محددة ولكن هناك نظريات…

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Does Using a Nasal Barrier Dressing Prevent Nasal Injury in Premature Infants Receiving Nasal Continuous Positive Airway Pressure?

Imbu­lana et al. The Jour­nal of Pedi­atrics 2018 In infants less than 30 weeks’ ges­ta­tion and/or with birth weight less than 1250 grams receiv­ing nasal con­tin­u­ous pos­i­tive air­way pres­sure (NCPAP), does the use of a bar­ri­er dress­ing com­pared with no bar­ri­er dress­ing decrease the inci­dence of nasal injury when used…

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Preterm Neuroimaging and School-Age Cognitive Outcomes

Hintz, et al. Pedi­atrics. 2018 In preterm infants <28 weeks ges­ta­tion,  do near-term con­ven­tion­al brain MRI find­ings  com­pared with adverse ear­ly and late cra­nial ultra­sound improve the pre­dic­tion of school age cog­ni­tive out­comes, when assessed between the age of 6 years 4 months to 7 years 2 months. Design: Neu­roimag­ing…

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ROTAVIRUS VACCINE FOR NEONATES

Bines, et al. Human. New Eng­land Jour­nal of Med­i­cine. 2018 QUESTION In healthy term neonates, is oral human rotavirus vac­cine admin­is­tered on a neona­tal sched­ule or infant sched­ule more effec­tive than place­bo at pre­vent­ing rotavirus gas­troen­teri­tis until age 18 months? Design: A ran­domised, dou­ble-blind, par­al­lel group, place­bo-con­trolled tri­al. Oral human…

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Sepsis-Induced Immunosuppression in Neonates

Hib­bert et al, Front Pedi­atr. 2018 Abstract Neonates, espe­cial­ly those born preterm, are at increased risk of sep­sis and adverse long-term effects asso­ci­at­ed with infec­­tion-relat­ed inflam­ma­tion. Dis­tinct neona­tal immune respons­es and dys­reg­u­lat­ed inflam­ma­tion are cen­tral to this unique sus­cep­ti­bil­i­ty. The tra­di­tion­al sep­a­ra­tion of sep­sis into an ini­tial hyper-inflam­­ma­­to­ry response fol­lowed…

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Mupirocin for Staphylococcus aureus Decolonization of Infants in Neonatal Intensive Care Units

Kot­loff et al, Pedi­atrics. 2019 Jan Abstract BACKGROUND AND OBJECTIVES: Staphy­lo­coc­cus aureus (SA) is the sec­ond lead­ing cause of late-onset sep­sis among infants in the NICU. Because col­o­niza­tion of nasal mucosa and/or skin fre­quent­ly pre­cedes inva­sive infec­tion, decol­o­niza­tion strate­gies, such as mupirocin appli­ca­tion, have been attempt­ed to pre­vent clin­i­cal infec­tion,…

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Initial antimicrobial treatment of foals with sepsis: Do our choices make a difference?

Thee­len et al, Vet J. 2019 Jan Abstract The study objec­tives were to pro­vide cumu­la­tive antimi­cro­bial sus­cep­ti­bil­i­ty data at the patient lev­el and to eval­u­ate the effect of ini­tial antimi­cro­bial treat­ment on sur­vival in foals with sep­sis. Foals below 30days of age with a diag­no­sis of sep­sis, con­firmed by iso­la­tion…

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Symptomatic seizures in preterm newborns: a review on clinical features and prognosis

Spag­no­li et al, tal­ian Jour­nal of Pediatrics2018 Neona­tal seizures are the most com­mon neu­ro­log­i­cal event in new­borns, show­ing high­er preva­lence in preterm than in full-term infants. In the major­i­ty of cas­es they rep­re­sent acute symp­to­matic phe­nom­e­na, the main eti­olo­gies being intra­ven­tric­u­lar haem­or­rhage, hypox­ic-ischemic encephalopa­thy, cen­tral ner­vous sys­tem infec­tions and tran­sient…

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Adverse Effects of Treatment with Valproic Acid during the Neonatal Period

Bau­dou et al, Neu­ro­pe­di­atrics. 2018 Nov 19 Abstract INTRODUCTION:  Val­proic acid (VPA) is rarely used in neona­tal peri­od. In chil­dren under 2 years old, seri­ous adverse effects are appear to be more fre­quent. METHOD:  Full-term new­borns, hos­pi­tal­ized at the Toulouse CHU, who pre­sent­ed with neona­tal seizures and who received long-term…

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