Benign Neonatal Shudders, Shivers, Jitteriness, or Tremors: Early Signs of Vitamin D Deficiency

Collins & Young Pediatrics, July 2017 Abstract and tremors in the newborn period typically precipitate an extensive, invasive, and expensive search for the etiology. Vitamin D deficiency has not been historically included in the differential of tremors. We report a shivering, jittery newborn who was subjected to a battery of testing, with…

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Ventilator-Associated Pneumonia in Low Birth Weight Neonates at a Neonatal Intensive Care Unit: A Retrospective Observational Study

Lee et al, February 2017 Background Ventilator-associated pneumonia (VAP) is one of the most common healthcare-associated infections among ventilated patients. The aim of this study was to determine the clinical characteristics and risk factors for the development of VAP in intubated low birth weight (LBW) neonates in a neonatal intensive care…

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Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial.

Steinhorn et al, J Pediatr. 2016 Oct Abstract OBJECTIVE: To evaluate the efficacy, safety, and pharmacokinetics of the endothelin receptor antagonist bosentan as adjunctive therapy for neonates with persistent pulmonary hypertension of the newborn (PPHN). STUDY DESIGN: This was a phase 3, multicenter, randomized, placebo-controlled exploratory trial (FUTURE-4). Eligible patients were >34 weeks gestation, <7 days old,…

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Risk Factors for Necrotizing Enterocolitis in Neonates: A Retrospective Case-Control Study

Lu et al, April 2017 Background Necrotizing enterocolitis (NEC) in neonates is devastating, and risk-factor identification is crucial. This study aimed to evaluate risk factors for NEC in different gestational age (GA) groups. Methods Risk factors associated with NEC were investigated using a retrospective case-control design.   Conclusion Intrahepatic cholestasis of…

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Probiotics Prevent Candida Colonization and Invasive Fungal Sepsis in Preterm Neonates: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Hua-Jian Hu, Pediatrics & neonatology, April 2017 To investigate whether probiotic supplementation could reduce the risk of fungal infection in preterm neonates in neonatal intensive care units (NICUs) The outcomes of interest were Candida colonization and invasive fungal sepsis. Seven trials involving 1371 preterm neonates were included. Limited data support that probiotic…

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Continuous Glucose Monitoring in Very Preterm Infants: A Randomized Controlled Trial

Galderisi et al, Pediatrics, October 2017, VOLUME 140 / ISSUE 4 Abstract BACKGROUND AND OBJECTIVES: Impaired glucose control in very preterm infants is associated with increased morbidity, mortality, and poor neurologic outcome. Strategies based on insulin titration have been unsuccessful in achieving euglycemia in absence of an increase in hypoglycemia and mortality.…

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Maternal and Placental Factors Associated with Congenital Hearing Loss in Very Preterm Neonates.

Kim et al, Pediatr Neonatol. 2017   BACKGROUND: Sensorineural hearing loss (SNHL) is a multifactorial disease that more frequently affects pretermnewborns. Although a number of maternal conditions have been reported to  be associated with preterm birth, little information is available concerning maternal risk factors for the development of SNHL. We aimed to identify maternaland placental risk factors associated with a “refer” result on the newborn hearing screening (NHS) test and subsequently confirmed SNHL in very preterm neonates.…

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Red Blood Cell Transfusion and Clinical Outcomes in Extremely Low Birth Weight Preterm Infants

Wang et al, Pediatr Neonatol. 2017  Background Red blood cell (RBC) transfusion is often considered a life-saving measure in critically ill neonates. The smallest and least mature  infants tend to receive the largest amount of transfusions. RBC transfusion itself has also been suggested as an independent risk facto r of poor…

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