Long-term effects of caffeine therapy for apnea of prematurity on sleep at school age

Mar­cus et al ‚Am J Respir Crit Care Med. 2014 Oct Abstract RATIONALE: Apnea of pre­ma­tu­ri­ty is a com­mon con­di­tion that is usu­al­ly treat­ed with caf­feine, an adeno­sine recep­tor block­er that has pow­er­ful influ­ences on the cen­tral ner­vous sys­tem. How­ev­er, lit­tle is known about the long-term effects of caf­feine on sleep in the devel­op­ing brain. OBJECTIVES:…

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Angiotensin-converting enzyme inhibitor nephrotoxicity in neonates with cardiac disease

Lin­dle KA, et al, Pedi­atr Car­di­ol. 2014 March Abstract Angiotensin-con­vert­ing enzyme inhibitors (ACEi) are com­mon­ly used for pedi­atric car­di­ol­o­gy patients. How­ev­er, stud­ies exam­in­ing their safe­ty for neonates with car­diac dis­ease are scarce. The cur­rent study aimed to test the hypoth­e­sis that ACEi-medi­at­ed nephro­tox­i­c­i­ty occurs in neonates and may be under­ap­pre­ci­at­ed in this pop­u­la­tion.…

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Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full-term infants.

Yahia et al, Eur J Pedi­atr. 2015 Apr Abstract Con­cerns of pos­si­ble geno­tox­ic effects of hyper­biliru­bine­mia and pho­tother­a­py were raised from exper­i­men­tal and obser­va­tion­al stud­ies in neonates. This study aimed to assess the impact of hyper­biliru­bine­mia and pho­tother­a­py on DNA dam­age and apop­to­sis in periph­er­al blood lym­pho­cytes in healthy full-term infants.…

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Jaundice, phototherapy and DNA damage in full-term neonates.

Ramy et al, J Peri­na­tol. 2016 Feb Abstract OBJECTIVE: Pho­tother­a­py is the stan­dard ther­a­peu­tic approach for neona­tal hyper­biliru­bine­mia. Oxida­tive effects of pho­tother­a­py may have poten­tial harms, includ­ing DNA dam­age. Uncon­ju­gat­ed biliru­bin (UCB) might also pos­sess antigeno­tox­ic poten­tial. Inten­sive pho­tother­a­py is more effi­ca­cious than con­ven­tion­al pho­tother­a­py in treat­ing hyper­biliru­bine­mia. This study aimed…

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Apnea of Prematurity.

AAP Issues Guid­ance on Apnea of Pre­ma­tu­ri­ty. Pedi­atrics, Jan­u­ary 2016, Eric C. Eichen­wald, COMMITTEE ON FETUS AND NEWBORN, From the Amer­i­can Acad­e­my of Pedi­atrics, Clin­i­cal Report Abstract   Apnea of pre­ma­tu­ri­ty is one of the most com­mon diag­noses in the NICU. Despite the fre­quen­cy of apnea of pre­ma­tu­ri­ty, it is unknown whether recur­rent apnea, brady­car­dia, and…

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Neonatal glucocorticoid treatment: long-term effects on the hypothalamus-pituitary-adrenal axis, immune system, and problem behavior in 14–17 year old adolescents

Ter Wol­beek et al, Brain Behav Immun. 2015 Mar Neona­tal glu­co­cor­ti­coid (GC) treat­ment is used to pre­vent bron­chopul­monary dys­pla­sia (BPD) in pre­ma­ture­ly born babies. In the 1990s, treat­ment reg­i­mens with rel­a­tive­ly high dos­es of dex­am­etha­sone (DEX) were com­mon. As an alter­na­tive, hydro­cor­ti­sone (HC) was used. Ear­li­er, we com­pared long-term effects of both GCs in chil­dren aged 7–10…

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Fetal antiepileptic drug exposure: Adaptive and emotional/behavioral functioning at age 6years

Cohen et al, Epilep­sy Behav. 2013 Nov The Neu­rode­vel­op­men­tal Effects of Antiepilep­tic Drugs (NEAD) study is a prospec­tive obser­va­tion­al mul­ti­cen­ter study in the USA and UK, which enrolled preg­nant women with epilep­sy on antiepilep­tic drug (AED) monother­a­py from 1999 to 2004. The study aimed to deter­mine if dif­fer­en­tial long-term neu­rode­vel­op­men­tal effects exist…

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Supraventricular tachycardia after nebulized salbutamol therapy in a neonate: case report

Say et al, Arch Argent Pedi­atr. 2015 Apr;  Abstract Supraven­tric­u­lar tachy­car­dia (SVT) is the most com­mon sus­tained arrhyth­mia in neonates and infants. Pre­sen­ta­tion of SVT in the neonate is usu­al­ly sub­tle and fre­quent­ly com­pli­cat­ed by con­ges­tive heart fail­ure. Despite the wide­spread use of β2-ago­nists, their safe­ty has been ques­tioned. Sev­er­al stud­ies have report­ed an increased inci­dence…

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The effect of erythropoietin on the severity of retinopathy of prematurity.

Kan­dasamy, Eye (Lond). 2014 July Abstract Exoge­nous human ery­thro­poi­etin (EPO) arti­fi­cial­ly syn­the­sised through recom­bi­nant DNA tech­nol­o­gy (rHuE­PO) is cur­rent­ly used as a sub­sti­tute for blood trans­fu­sion in preterm and low birth weight neonates. The objec­tive of this study is to deter­mine whether the use of rHuE­PO is asso­ci­at­ed with an increased sever­i­ty of retinopa­thy…

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Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants

Clemin­son, et al, Sept 2015 The Cochrane Library Abstract Back­ground Inva­sive fun­gal infec­tion is an impor­tant cause of mor­tal­i­ty and mor­bid­i­ty in very preterm and very low birth weight infants. Ear­ly diag­no­sis is dif­fi­cult and treat­ment is often delayed. Sys­tem­i­cal­ly absorbed anti­fun­gal agents (usu­al­ly azoles) are increas­ing­ly used as pro­phy­lax­is…

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