Clinical pharmacology of furosemide in neonates: a review.

Paci­fi­ci, Phar­ma­ceu­ti­cals (Basel), 2013 Abstract Furosemide is the diuret­ic most used in new­born infants. It blocks the Na+-K+-2Cl- sym­porter in the thick ascend­ing limb of the loop of Hen­le increas­ing uri­nary excre­tion of Na+ and Cl-. This arti­cle aimed to review the pub­lished data on the clin­i­cal phar­ma­col­o­gy of furosemide in neonates…

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Pharmacological Therapy of Gastroesophageal Reflux in Preterm Infants

Cor­vaglia et al, Gas­troen­terol­o­gy Research and Prac­tice, Vol­ume 2013 (2013) Abstract Although gas­troe­sophageal reflux (GER) is a very com­mon phe­nom­e­non among preterm infants, its ther­a­peu­tic man­age­ment is still an issue of debate among neona­tol­o­gists. A step-wise approach should be advis­able, first­ly pro­mot­ing non­phar­ma­co­log­i­cal inter­ven­tions and lim­it­ing drugs to select­ed infants unre­spon­sive to the con­ser­v­a­tive…

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Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns

Ter­rin et al, Pedi­atrics, 2012 Gas­tric acid­i­ty is a major non­im­mune defense mech­a­nism against infec­tions. The objec­tive of this study was to inves­ti­gate whether ran­i­ti­dine treat­ment in very low birth weight (VLBW) infants is asso­ci­at­ed with an increased risk of infec­tions, necro­tiz­ing ente­ro­col­i­tis (NEC), and fatal out­come. RESULTS: We eval­u­at­ed 274 VLBW

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Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants

Smit et al, 2013, Cochrane neona­tol­ogy group Intra­ven­tric­u­lar haem­or­rhage (IVH) is a major com­pli­ca­tion of preterm birth. Large haem­or­rhages are asso­ci­at­ed with a high risk of dis­abil­i­ty and hydro­cephalus. Insta­bil­i­ty of blood pres­sure and cere­bral blood flow are pos­tu­lat­ed as causative fac­tors. Anoth­er mech­a­nism may involve reper­fu­sion dam­age from oxy­gen…

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A propensity-matched cohort study of vancomycin-associated nephrotoxicity in neonates

Con­stance et al, Arch Dis Child Fetal Neona­tal Ed. 2015 Sep 23.  BACKGROUND: The inci­dence of nephro­tox­i­c­i­ty among van­­comycin-treat­ed neonates has been report­ed to range from 2% to 20%. These wide­ly vary­ing esti­mates have led to con­fu­sion and con­tro­ver­sy regard­ing the safe­ty of van­comycin among neonates. OBJECTIVE: Eval­u­ate the inci­dence of nephro­tox­i­c­i­ty among neonates receiv­ing van­comycin con­comi­tant­ly…

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Long-term effects of caffeine therapy for apnea of prematurity on sleep at school age

Am J Respir Crit Care Med.  2014; Mar­cus et al RATIONALE: Apnea of pre­ma­tu­ri­ty is a com­mon con­di­tion that is usu­al­ly treat­ed with caf­feine, an adeno­sine recep­tor block­er that has pow­er­ful influ­ences on the cen­tral ner­vous sys­tem. How­ev­er, lit­tle is known about the long-term effects of caf­feine on sleep in the…

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Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates

Cochrane review, 18 Feb­ru­ary 2015 Back­ground Estab­lish­ment of secure air­way is a crit­i­cal part of neona­tal resus­ci­ta­tion both in the deliv­ery room and in the neona­tal unit. Vide­o­laryn­goscopy is a new tech­nique that has the poten­tial to facil­i­tate suc­cess­ful endo­tra­cheal intu­ba­tion and decrease adverse con­se­quences of delay in air­way sta­bi­liza­tion.…

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Variation in Prenatal Diagnosis of Congenital Heart Disease in Infants

 Quar­ter­main, et al Pedi­atrics, 2015 .  ABSTRACT BACKGROUND AND OBJECTIVE: Pre­na­tal diag­no­sis allows improved peri­op­er­a­tive out­comes for fetus­es with cer­tain forms of con­gen­i­tal heart dis­ease (CHD). Vari­abil­i­ty in pre­na­tal diag­no­sis has been demon­strat­ed in oth­er coun­tries, lead­ing to efforts to improve fetal imag­ing pro­to­cols and access to care, but has…

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