Morgan J, Young L, McGuire W, 1 December 2014
Very preterm (less than 32 weeks' gestation) or very low birth weight (less than 1500 g) infants are at of developing a severe bowel disorder called necrotising enterocolitis, where parts of the bowel become inflamed and start to die. One possible way to prevent this condition is to delay the introduction of milk feeds until several days (or longer) after birth.
The introduction of enteral feeds for very preterm (less than 32 weeks' gestation) or very low birth weight (VLBW; less than 1500 g) infants is often delayed for several days or longer after birth due to concern that early introduction may not be tolerated and may increase the of necrotising enterocolitis (NEC). However, delaying enteral feeding could diminish the functional adaptation of the gastrointestinal tract and prolong the need for parenteral nutrition with its attendant infectious and metabolic risks.
To determine the effect of delayed introduction of progressive enteral feeds on the incidence of NEC, and other morbidities in very preterm or VLBW infants.
We identified nine randomised controlled trials in which 1106 infants participated. Few participants were extremely preterm (less 28 weeks' gestation) or extremely low birth weight (less than 1000 g). The trials defined delayed introduction of progressive enteral feeds as later than four to seven days after birth and early introduction as four days or less after birth. Meta-analyses did not detect effects on the of NEC
The evidence available from randomised controlled trials suggested that delaying the introduction of progressive enteral feeds beyond four days after birth did not reduce the of developing NEC in very preterm or VLBW infants, including growth-restricted infants. Delaying the introduction of progressive enteral feeds resulted in a few days' delay in establishing full enteral feeds but the clinical importance of this effect was unclear. The applicability of these findings to extremely preterm or extremely low birth weight was uncertain. Further randomised controlled trials in this may be warranted.