Inositol in preterm infants at risk for or having respiratory distress syndrome

Alexandra Howlett1,et al. Editorial Group: Cochrane Neonatal Group, Published Online: 4 FEB 2015

Inositol is an essential nutrient required by human cells in culture for growth and survival. Inositol promotes maturation of several components of surfactant and may play a critical role in fetal and early neonatal life.

Authors' conclusions

 Inositol supplementation results in statistically significant and clinically important reductions in important short-term adverse neonatal outcomes. A large size multi-centre randomised controlled trial is currently ongoing and the trial will likely confirm or refute the findings from this systematic review.