Gastric acidity is a major nonimmune defense mechanism against infections. The objective of this study was to investigate whether ranitidine treatment in very low birth weight (VLBW) infants is associated with an increased risk of infections, necrotizing enterocolitis (NEC), and fatal outcome.
We evaluated 274 VLBW infants: 91 had taken ranitidine and 183 had not. The main clinical and demographic characteristics did not differ between the 2 groups. Thirty-four (37.4%) of the 91 children exposed to ranitidine and 18 (9.8%) of the 183 not exposed to ranitidine had contracted infections (odds ratio 5.5, 95% confidence interval 2.9-10.4, P < .001). The risk of NEC was 6.6-fold higher in ranitidine-treated VLBW infants (95% confidence interval 1.7-25.0, P = .003) than in control subjects. Mortality rate was significantly higher in newborns receiving ranitidine (9.9% vs 1.6%, P = .003).
Ranitidine therapy is associated with an increased risk of infections, NEC, and fatal outcome in VLBW infants. Caution is advocated in the use of this drug in neonatal age.
Facebook : PORT SAID EIGHTH NEONATOLOGY CONFERENCE 2017 SHARING STAFF: Prof Abla El Aalfy (Executive director of our dream project ) Prof Ahmed El Lawah (Alazhar univ) Prof Alaa Sobeih (Cairo univ) Prof Ahmed Amr Abbassy (Alexandria univ) Prof Atef Donia (Alazhar univ) Prof David Clark (USA) Dr.Elsayed Khalaf (Port Fouad hosp, Port…