Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: An RCT

Williams et al, Pediatrics, May 2017

Abstract

BACKGROUND: The recommendation for enteral iodide intake for preterm infants is 30 to 40 μg/kg per day and 1 μg/kg per day for parenteral intake. Preterm infants are vulnerable to iodide insufficiency and thyroid dysfunction. The hypothesis tested whether, compared with placebo, iodide supplementation of preterm infants improves neurodevelopment.

METHODS: A randomized controlled trial of iodide supplementation versus placebo in infants <31 weeks’ gestation. 

CONCLUSIONS: Overall iodide supplementation provided no benefit to neurodevelopment measured at 2 years of age.