Randomized Trial to Compare Renal Function and Ductal Response between Indomethacin and Ibuprofen Treatment in Extremely Low Birth Weight Infants

Lin et al, Neonatology, 2017

Abstract

Background: A head to head comparison study on renal function and ductal response between indomethacin and ibuprofen has rarely been conducted in extremely low birth weight (ELBW) infants.

Objectives: The aim was to compare renal function and ductal response between indomethacin and ibuprofen in ELBW infants.

Methods: a double-blind randomized control trial

Conclusions: With the current dosage, ibuprofen had fewer renal side effects but was associated with a lower rate of persistent ductal closure in ELBW infants.