Two-year development of children conceived by IVM: a prospective controlled single-blinded study

Roesner et al, Hum Reprod (2017) 



Is there a difference in mental development of children c

onceived by IVM in comparison to IVF or ICSI, independently, at the age of 2 years?


No differences could be found in mental development 

of IVM children compared to IVF and IVM children compared to ICSI as well.


Only few retrospective or non-controlled studies addressed the health of IVM children and did not show a negative impact of the IVM procedure.


Children conceived after IVM did not show differences during embryonic development, at birth nor in their neuropediatric development at the age of 2 compared to their counterparts after IVF and after ICSI (Bayley score 91.3 ± 21.0 for IVM, 96.8 ± 13.2 for IVF and 103.9 ± 13.1 for ICSI) and of the pooled ART group compared to children after spontaneous conception (96.6 ± 16.4 ART and 103.2 ± 9.4 spontaneous conception). When analyzing singleton pregnancies only, again no differences during pregnancy, at birth and at their 2-year evaluation were detected between IVM versus IVF and IVM versus ICSI.