Two-year development of children conceived by IVM: a prospective controlled single-blinded study

Roesner et al, Hum Reprod (2017) 

Abstract

STUDY QUESTION

Is there a difference in mental development of children c

onceived by IVM in comparison to IVF or ICSI, independently, at the age of 2 years?

SUMMARY ANSWER

No differences could be found in mental development 

of IVM children compared to IVF and IVM children compared to ICSI as well.

WHAT IS KNOWN ALREADY

Only few retrospective or non-controlled studies addressed the health of IVM children and did not show a negative impact of the IVM procedure.

 

Children conceived after IVM did not show differences during embryonic development, at birth nor in their neuropediatric development at the age of 2 compared to their counterparts after IVF and after ICSI (Bayley score 91.3 ± 21.0 for IVM, 96.8 ± 13.2 for IVF and 103.9 ± 13.1 for ICSI) and of the pooled ART group compared to children after spontaneous conception (96.6 ± 16.4 ART and 103.2 ± 9.4 spontaneous conception). When analyzing singleton pregnancies only, again no differences during pregnancy, at birth and at their 2-year evaluation were detected between IVM versus IVF and IVM versus ICSI.