Maternal and Placental Factors Associated with Congenital Hearing Loss in Very Preterm Neonates.

Kim et al, Pediatr Neonatol. 2017  


Sensorineural hearing loss (SNHL) is a multifactorial disease that more frequently affects pretermnewborns. Although a number of maternal conditions have been reported to 

be associated with preterm birth, little information is available concerning maternal risk factors for the development of SNHL. We aimed to identify maternaland placental risk factors associated with a “refer” result on the newborn hearing screening (NHS) test and subsequently confirmed SNHL in very preterm neonates.


Presence of funisitis was significantly and independently associated with increased risk of abnormal NHS results, while administration of antenatal corticosteroids was related to a normal NHS result. These findings support the hypothesis that a systemic fetal inflammatory response, manifested as funisitis, might play a role in the pathogenesis of SNHL in preterm neonates.