Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials

Roth et al, BMJ, 2017


Objectives: To estimate the effects of vitamin D supplementation during pregnancy on 11 maternal and 27 neonatal/infant outcomes; to determine frequencies at which trial outcome data were missing, unreported, or inconsistently reported; and to project the potential contributions of registered ongoing or planned trials.

Design: Systematic review and meta-analysis of randomised controlled trials; systematic review of registered but unpublished trials.

Conclusions: Most trials on prenatal vitamin D published by September 2017 were small and of low quality. The evidence to date seems insufficient to guide clinical or policy recommendations. Future trials should be designed and powered to examine clinical endpoints, including maternal conditions related to pregnancy (such as pre-eclampsia), infant growth, and respiratory outcomes.