Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia

Bassler et at, N Engl J Med. 2018 Jan

BACKGROUND :

The long-term effects on neurodevelopment of the use of inhaled glucocorticoids in extremely preterm infants for the prevention or treatment of bronchopulmonary dysplasia are uncertain.

 CONCLUSIONS

 

Among surviving extremely preterm infants, the rate of neurodevelopmental disability at 2 years did not differ significantly between infants who received early inhaled budesonide for the prevention of bronchopulmonary dysplasia and those who received placebo, but the mortality rate was higher among those who received budesonide