Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention

Fowler et al, N Engl J Med. 2016 Nov

 

Abstract

BACKGROUND:

Randomized-trial data on the risks and benefits of antiretroviral therapy (ART) as compared with zidovudine and single-dose nevirapine to prevent transmission of the human immunodeficiency virus (HIV) in HIV-infected pregnant women with high CD4 counts are lacking.

CONCLUSIONS:

Antenatal ART resulted in significantly lower rates of early HIV transmission than zidovudine alone but a higher risk of adverse maternal and neonatal outcomes.