Outcomes of Two Trials of Oxygen-Saturation Targets in Preterm Infants

N Engl J Med 2016


The safest ranges of oxygen saturation in preterm infants have been the subject of debate.



In two trials, conducted in Australia and the

United Kingdom, infants born before 28 weeks’ gestation were randomly assigned to either a lower (85 to 89%) or a higher (91 to 95%) oxygen-saturation range. 


Use of an oxygen-saturation target range of 85 to 89% versus 91 to 95% resulted in nonsignificantly higher rates of death or disability at 2 years in each trial but in significantly increased risks of this combined outcome and of death alone in post hoc combined analyses.