Impact of Minimally Invasive Surfactant Therapy in Preterm Infants at 29–32 Weeks Gestation

Dargaville et al, Neonatology 2018


Background: Most preterm infants born at 29–32 weeks gestation now avoid intubation in early life, and thus lack the usual conduit through which exogenous surfactant is given if needed. Objective: The aim of this work was to examine whether a technique of minimally invasive surfactant therapy used selectively at 29–32 weeks gestation would improve outcomes. Conclusions: Selective use of minimally invasive surfactant therapy at 29–32 weeks gestation permits a primary CPAP strategy to be pursued with a high rate of success, and a low risk of pneumothorax.

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