Prophylactic treatment for sepsis. The Egyptian Consensus on the Management of Neonatal Respiratory Distress Syndrome 2017

NEONATAL CARE NETWORK 2017 (NCN) 

Recommendations

1. Infection control measures should be strictly applied

 2. Antibiotics are often started in babies with RDS until sepsis has been ruled out, but policies should be in place to narrow the spectrum and minimize unnecessary exposure. A common regimen includes penicillin or ampicillin in combination with an aminoglycoside (D2). Antibiotics should be stopped as soon as possible once sepsis has been excluded (C1).

3. In units with a high rate of invasive fungal infection, prophylaxis with fluconazole or oral nystatin is recommended in babies with a birth weight <1,500 g, or those with gestation periods ≤ 27 weeks. Treatment should be initiated on day one of life. Fluconazols dose is 3 mg/kg, twice weekly, should be administered for a total of six weeks. Oral nystatin dose is 100,000 units every 8 hours (A).

  • Qual­i­ty of evi­dence
   – High qual­i­ty A    – Mod­er­ate qual­i­ty B    – Low qual­i­ty C    – Very low qual­i­ty D MODIFIED FROM: Euro­pean Con­sen­sus Guide­lines on the Man­age­ment of Res­pi­ra­to­ry Dis­tress Syn­drome – 2016 Update Spon­sored by: abb­vie EGYPT Shar­ing pro­fes­sors:
  • Prof Abdel Rah­man El Mashad (Tan­ta univ)
  • Prof Afaf Kor­raa (Azhar univ)
  • Prof El Sayed Kha­laf (Port fouad hosp, min­istry of health)
  • Prof Iman Eskan­der (Cairo univ)
  • Prof Hes­ham Abdel Hady (Man­soura univ)
  • Prof Hes­ham Ghaz­al (Alexan­dria univ)
  • Prof Mag­da Badawy (Cairo univ)
  • Prof Madi­ha Abdal­la (Minia univ)
  • Prof Magdy Kamel (Minia univ)
  • Prof M Abdel Aaal El Bagy (Sohag univ)
  • Prof Morad El Alfy (Al Galaa mil­i­tary cen­ter)
  • Prof Nahed Fah­my (Cairo univ)
  • Prof Nay­era Ismaeil (Ain Shams univ)
  • Prof Raguia Atwa (Ain Shams univ)
  • Prof Safaa Shafeek (Ain Shams univ)
  • Prof Sozan Gad (Suez canal univ)
  • Prof Osama Hus­sein (Port said neona­tol­ogy soci­ety)
  • Prof Osama Kasem (Al Galaa mil­i­tary cen­ter)
  • Prof Yehia Mah­moud Basha (Daman­hour teach­ing hosp)
  • Prof Zahraa Ezz El Deen (Cairo univ)