Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants

Lod­ha et al, Pedi­atrics. 2018 Dec


Although caf­feine use for apnea of pre­ma­tu­ri­ty is well stud­ied, the long-term safe­ty and ben­e­fit of rou­tine ear­ly caf­feine admin­is­tra­tion has not been explored. Our objec­tive was to deter­mine the asso­ci­a­tion between ear­ly (with­in 2 days of birth) ver­sus late caf­feine expo­sure and neu­rode­vel­op­men­tal out­comes in preterm infants.


Ear­ly caf­feine ther­a­py is asso­ci­at­ed with bet­ter neu­rode­vel­op­men­tal out­comes com­pared with late caf­feine ther­a­py in preterm infants born at <29 weeks’ ges­ta­tion.

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