Preterm Neuroimaging and School-Age Cognitive Outcomes

Hintz, et al. Pedi­atrics. 2018

In preterm infants <28 weeks ges­ta­tion,  do near-term con­ven­tion­al brain MRI find­ings  com­pared with adverse ear­ly and late cra­nial ultra­sound improve the pre­dic­tion of school age cog­ni­tive out­comes, when assessed between the age of 6 years 4 months to 7 years 2 months.

Design: Neu­roimag­ing and neu­rode­vel­op­men­tal Out­comes (NEURO) study was a prospec­tive mul­ti cen­ter cohort study. The par­tic­i­pat­ing cen­ters were from NICHD NRN.  It is a sec­ondary study  to the SUPPORT study. This study was approved by insti­tu­tion­al review boards of par­tic­i­pat­ing cen­ters. The SUPPORT study was prospec­tive­ly reg­is­tered with clin­i­cal Tri­als


The authors con­clude that adverse late CUS find­ings were most strong­ly asso­ci­at­ed with cog­ni­tive impair­ment and dis­abil­i­ty at school age. Sig­nif­i­cant cere­bel­lar lesions on MRI were also asso­ci­at­ed with dis­abil­i­ty. Near-term con­ven­tion­al MRI did not sub­stan­tial­ly enhance the pre­dic­tion of severe ear­ly school-age out­comes.

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