Hintz, et al. Pediatrics. 2018
In preterm infants <28 weeks gestation, do near-term conventional brain MRI findings compared with adverse early and late cranial ultrasound improve the prediction of school age cognitive outcomes, when assessed between the age of 6 years 4 months to 7 years 2 months.
Design: Neuroimaging and neurodevelopmental Outcomes (NEURO) study was a prospective multi center cohort study. The participating centers were from NICHD NRN. It is a secondary study to the SUPPORT study. This study was approved by institutional review boards of participating centers. The SUPPORT study was prospectively registered with clinical Trials
The authors conclude that adverse late CUS findings were most strongly associated with cognitive impairment and disability at school age. Significant cerebellar lesions on MRI were also associated with disability. Near-term conventional MRI did not substantially enhance the prediction of severe early school-age outcomes.