Christensen et al, JAMA, Jan 2019
Importance Valproate is an antiepileptic drug (AED) used in the treatment of epilepsy and many other neurological and psychiatric disorders. Its use in pregnancy is associated with increased risks of congenital malformations and adverse neurodevelopment in the offspring and may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD).
Objective To determine whether prenatal exposure to valproate and other AEDs is associated with an increased risk of ADHD in the offspring.
Exposures Maternal use of valproate and other AEDs in pregnancy.
Main Outcomes and Measures Cox regression estimates of the hazard ratio of ADHD. Estimates were adjusted for potential confounders.
Conclusions and Relevance Maternal use of valproate, but not other AEDs, during pregnancy was associated with an increased risk of ADHD in the offspring. These findings have important implications for the counseling of women of childbearing potential using valproate.