Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: An RCT

Williams et al, Pediatrics, May 2017 Abstract BACKGROUND: The recommendation for enteral iodide intake for preterm infants is 30 to 40 μg/kg per day and 1 μg/kg per day for parenteral intake. Preterm infants are vulnerable to iodide insufficiency and thyroid dysfunction. The hypothesis tested whether, compared with placebo, iodide supplementation of…

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Faster clean catch urine collection (Quick-Wee method) from infants: randomised controlled trial

Kaufman et al, BMJ 2017 Objective To determine if a simple stimulation method increases the rate of infant voiding for clean catch urine within five minutes. Gentle suprapubic cutaneous stimulation using gauze soaked in cold fluid is used. Design Randomised controlled trial. Main outcome measures The primary outcome was voiding of urine within five…

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Mid-Childhood Bone Mass After Exposure to Repeat Doses of Antenatal Glucocorticoids: A Randomized Trial

Christopher et al, Pediatrics, 2017 Abstract BACKGROUND AND OBJECTIVE: Treatment of women at risk for preterm birth with repeat doses of glucocorticoids reduces neonatal morbidity, but could have adverse effects on skeletal development. We assessed whether exposure to repeat antenatal betamethasone alters bone mass in children whose mothers participated in…

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Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis

Hendrik et al, Pediatrics, April 2017 Abstract CONTEXT: Recombinant human erythropoietin (rhEPO) is a promising pharmacological agent for neuroprotection in neonates. OBJECTIVE: To investigate whether prophylactic rhEPO administration in very preterm infants improves neurodevelopmental outcomes in a meta-analysis of randomized controlled trials (RCTs). DATA SOURCES: Medline, Embase, and the Cochrane…

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Body Composition in Very Preterm Infants: Role of Neonatal Characteristics and Nutrition in Achieving Growth Similar to Term Infants

Tremblay et al, Neonatology 2017 Abstract Background: The identification of factors involved in the postnatal growth of preterm infants will help achieve growth similar to that of term infants. Objectives: As per protocol: to compare body composition in very preterm infants at term-corrected age (TCA) with that in term infants, and…

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Vitamin D for the management of asthma.

Martineau et al, Cochrane Review, September 2016 Abstract Background: Several clinical trials of vitamin D to prevent asthma exacerbation and improve asthma control have been conducted in children and adults, but a meta-analysis restricted to double-blind, randomised, placebo-controlled trials of this intervention is lacking. Authors’ conclusions: Whilst we are confident that Vitamin D reduced…

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Association Between Early Low-Dose Hydrocortisone Therapy in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years of Age

Baud et al,  JAMA. 2017 Dexamethasone to prevent bronchopulmonary dysplasia in very preterm neonates was associated with adverse neurodevelopmental events. Early low-dose hydrocortisone treatment has been reported to improve survival without bronchopulmonary dysplasia but its safety with regard to neurodevelopment remains to be assessed. In an exploratory analysis of secondary…

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Bacteremia in Children 3 to 36 Months Old After Introduction of Conjugated Pneumococcal Vaccines

Greenhow et al, Pediatrics, March 2017 Abstract BACKGROUND AND OBJECTIVES: In June 2010, Kais er Permanente Northern California replaced all 7-valent pneumococcal conjugate vaccine (PCV7) vaccines with the 13-valent pneumococcal conjugate vaccine (PCV13). Our objectives were to compare the incidence of bacteremia in children 3 to 36 months old by 3…

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