Association Between Laboratory Calibration of a Serum Bilirubin Assay, Neonatal Bilirubin Levels, and Phototherapy Use

Kuzniewicz et al, JAMA Pedi­atr. April 11, 2016 Impor­tance  The Amer­i­can Acad­e­my of Pedi­atrics treat­ment rec­om­men­da­tions for neona­tal jaun­dice are based on age-spe­cif­ic total serum biliru­bin (TSB) lev­els. In May 2012, Ortho Clin­i­cal Diag­nos­tics adjust­ed the cal­i­bra­tor val­ues for Vit­ros Chem­istry Prod­ucts BuBc Slides (Ortho Clin­i­cal Diag­nos­tics), a wide­ly used method…

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Impact of antenatal steroids on intraventricular hemorrhage in very-low-birth weight infants

Wei et al, Jour­nal of Peri­na­tol­ogy, March 2016 Objec­tive: To deter­mine the asso­ci­a­tion between ante­na­tal steroids admin­is­tra­tion and intra­ven­tric­u­lar hem­or­rhage rates. Results: In 25 979 very-low-birth weight infants, ante­na­tal steroid use was asso­ci­at­ed with a reduc­tion in inci­dence of any grade of intra­ven­tric­u­lar hem­or­rhage (odds ratio=0.68, 95% con­fi­dence inter­val: 0.62, 0.75) and a reduc­tion in…

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Neuroimaging identifies increased manganese deposition in infants receiving parenteral nutrition.

Aschn­er et al, Am J Clin Nutr. 2015 Dec Abstract BACKGROUND: Man­ganese, an essen­tial met­al for nor­mal growth and devel­op­ment, is neu­ro­tox­ic on exces­sive expo­sure. Stan­dard trace ele­ment-sup­ple­ment­ed neona­tal par­enter­al nutri­tion (PN) has a high man­ganese con­tent and bypass­es nor­mal gas­troin­testi­nal absorp­tive con­trol mech­a­nisms, which places infants at risk of man­ganese…

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Failed endotracheal intubation and adverse outcomes among extremely low birth weight infants.

Wal­len­stein et al, J Peri­na­tol. 2016 Feb Abstract OBJECTIVE: To quan­ti­fy the impor­tance of suc­cess­ful endo­tra­cheal intu­ba­tion on the first attempt among extreme­ly low birth weight (ELBW) infants who require resus­ci­ta­tion after deliv­ery. RESULTS: The study sam­ple includ­ed 88 ELBW infants. Forty per­cent were intu­bat­ed on the first attempt and 60%…

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Pathogen-Specific Clustering of Nosocomial Blood Stream Infections in Very Preterm Infants

Reichert et al, Pedi­atrics, March 2016 Abstract BACKGROUND AND OBJECTIVES: Noso­co­mi­al infec­tions in NICUs tend to clus­ter, some­times as dev­as­tat­ing out­breaks, but pathogen-spe­cif­ic trans­mis­sion prob­a­bil­i­ties are unknown. We aimed to quan­ti­fy the pathogen-spe­cif­ic risk of a blood stream infec­tion (BSI) in preterm infants after an index case with that pathogen…

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A Multifaceted Approach to Improving Outcomes in the NICU: The Pediatrix 100 000 Babies Campaign

Ells­bury et al, Pedi­atrics, April, 2016 Abstract BACKGROUND AND OBJECTIVE: Despite advances in neona­tal med­i­cine, infants requir­ing neona­tal inten­sive care con­tin­ue to expe­ri­ence sub­stan­tial mor­bid­i­ty and mor­tal­i­ty. The pur­pose of this ini­tia­tive was to gen­er­ate large-scale simul­ta­ne­ous improve­ments in mul­ti­ple domains of care in a large neona­tal net­work through a…

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Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial

Baud et al, Lancet, Feb­ru­ary, 2016 Abstract BACKGROUND: Bron­chopul­monary dys­pla­sia, a major com­pli­ca­tion of extreme pre­ma­tu­ri­ty, has few treat­ment options. Post­na­tal steroid use is con­tro­ver­sial, but low-dose hydro­cor­ti­sone might pre­vent the harm­ful effects of inflam­ma­tion on the devel­op­ing lung. In this study, we aimed to assess whether low-dose hydro­cor­ti­sone improved…

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Rumpel-Leede Phenomenon Associated With Tourniquet-like Forces of Baby Carriers in Otherwise Healthy Infants Baby Carrier Purpura

Naguyen et al, JAMA Der­ma­tol. 2016 Feb 17. A case report described acute-onset low­er-extrem­i­ty petechi­ae and pur­pu­ra caused by der­mal cap­il­lary rup­ture from a baby car­ri­er in oth­er­wise healthy infants (Rumpel-Leede phe­nom­e­non). Acute-onset, local­ized petechi­ae and pur­pu­ra of the low­er extrem­i­ties occurred in 3 oth­er­wise healthy infants fol­low­ing recent expo­sure to baby…

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Impact of Donor Milk Availability on Breast Milk Use and Necrotizing Enterocolitis Rates

Abstract OBJECTIVES: To exam­ine the avail­abil­i­ty of donor human milk (DHM) in a pop­u­la­tion-based cohort and assess whether the avail­abil­i­ty of DHM was asso­ci­at­ed with rates of breast milk feed­ing at NICU dis­charge and rates of necro­tiz­ing ente­ro­col­i­tis (NEC). METHODS: Indi­vid­ual patient clin­i­cal data for very low birth weight infants…

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Benefits of Delayed Cord Clamping in Red Blood Cell Alloimmunization

Garabe­di­an et al, Pedi­atrics, March, 2016 Abstract BACKGROUND AND OBJECTIVE: Sev­er­al stud­ies have shown the ben­e­fits of delayed cord clamp­ing (DCC) in preterm and in healthy new­borns at short and long term. Our objec­tive was to eval­u­ate the poten­tials ben­e­fits and risks of DCC in red cell alloim­mu­niza­tion. RESULTS: We…

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