Brief Resolved Unexplained Events (Formerly Apparent Life-Threatening Events) and Evaluation of Lower-Risk Infants

Pedi­atrics, April 2016, From the Amer­i­can Acad­e­my of Pedi­atrics, Clin­i­cal Prac­tice Guide­line This is the first clin­i­cal prac­tice guide­line from the Amer­i­can Acad­e­my of Pedi­atrics that specif­i­cal­ly applies to patients who have expe­ri­enced an appar­ent life-threat­en­ing event (ALTE). This clin­i­cal prac­tice guide­line has 3 objec­tives. First, it rec­om­mends the replace­ment of the…

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Early removal versus expectant management of central venous catheters in newborn infants with bloodstream infection

Vasude­van et al, 20 April 2016,Cochrane review Review ques­tion: In new­born infants with a blood­stream infec­tion who have a cen­tral venous catheter in place, does ear­ly removal of the catheter reduce the riskof com­pli­ca­tions, includ­ing death and long-term dis­abil­i­ty? Back­ground: Infec­tion in the blood­stream is a fre­quent and harm­ful com­pli­ca­tion for new­born infants who have a cen­tral venous catheter (a can­nu­la that extends sev­er­al…

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Association of Serum Albumin Level and Mortality in Premature Infants

Tor­er et al, J Clin Lab Anal. 2016  Abstract BACKGROUND: Hypoal­bu­mine­mia has been proven to be a pow­er­ful pre­dic­tor of mor­tal­i­ty in adult patients. How­ev­er, prog­nos­tic val­ue of serum albu­min in neonates is not clear. OBJECTIVE: To assess the rela­tion­ship between serum albu­min lev­el with­in the first day of life and out­come…

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Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis fromSepsis in Early Stage of the Disease.

Coufal et al, Immunol Res. 2016 Abstract Necro­tiz­ing ente­ro­col­i­tis (NEC) is severe dis­ease of gas­troin­testi­nal tract, yet its ear­ly symp­toms are non­spe­cif­ic, eas­i­ly inter­change­able with sep­sis. There­fore, reli­able bio­mark­ers for ear­ly diag­nos­tics are need­ed in clin­i­cal prac­tice. Here, we ana­lyzed if mark­ers of gut mucosa dam­age, cas­pase cleaved cytok­er­atin 18 (ccCK18)…

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Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates

Fos­ter JP, Cole MJ, Seth R, 4 April 2016, Cochrane review Review ques­tion: Does the use of oral immunoglob­u­lin reduce the inci­dence of necro­tiz­ing ente­ro­col­i­tis and oth­er com­pli­ca­tions in preterm or low birth weight (or both) neonates? Back­ground: Immunoglob­u­lin giv­en oral­ly for pre­vent­ing emer­gency intesti­nal prob­lems (necro­tiz­ing ente­ro­col­i­tis) in pre­ma­ture and low birth weight new­born infants. Destruc­tive inflam­ma­tion…

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Risk Factors for Neurotoxicity in Newborns With Severe Neonatal Hyperbilirubinemia

Rasha Gamaleldin, Iman Iskan­der, Iman Seoud, Hanan Abo­raya, Alek­san­dr Aravkin, Paul D. Samp­son, Richard P. Wennberg, Pedi­atrics, Octo­ber 2011, VOLUME 128 / ISSUE 4   Abstract OBJECTIVE: To eval­u­ate the impor­tance of total serum biliru­bin (TSB) and neu­ro­tox­i­c­i­ty risk fac­tors in pre­dict­ing acute biliru­bin encephalopa­thy (ABE) at admis­sion or post­treat­ment biliru­bin encephalopa­thy (BE) in infants with severe hyper­biliru­bine­mia.…

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The effects of inhaled albuterol in transient tachypnea of the newborn

Kim et al, Aller­gy Asth­ma Immunol Res. 2014 Mar; Abstract PURPOSE: Tran­sient tachyp­nea of the new­born (TTN) is a dis­or­der caused by the delayed clear­ance of fetal alve­o­lar flu­id. β-adren­er­g­ic ago­nists such as albuterol (salbu­ta­mol) are known to cat­alyze lung flu­id absorp­tion. This study exam­ined whether inhala­tion­al salbu­ta­mol ther­a­py could improve clin­i­cal symp­toms in TTN.…

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Effects of ventilation on hearing loss in preterm neonates: Nasal continuous positive pressure does not increase the risk of hearing loss in ventilated neonates

Ras­to­gi et al, Int J Pedi­atr Otorhi­no­laryn­gol. 2013 Mar Abstract INTRODUCTION: There is increased risk of hear­ing loss in preterm neonates. This risk is fur­ther increased by envi­ron­men­tal noise expo­sure espe­cial­ly from life sup­port equip­ment such as ven­ti­la­tion. Nasal con­tin­u­ous pos­i­tive air­way pres­sure (NCPAP) used for res­pi­ra­to­ry sup­port of preterm neonates is…

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Short Maternal Stature Increases Risk of Small-for-Gestational-Age and Preterm Births in Low- and Middle-Income Countries

Indi­vid­ual Par­tic­i­pant Data Meta-Analy­sis and Pop­u­la­tion Attrib­ut­able Frac­tion. Kozu­ki et al, J Nutr. 2015 BACKGROUND: Small-for-ges­ta­tion­al-age (SGA) and preterm births are asso­ci­at­ed with adverse health con­se­quences, includ­ing neona­tal and­in­fant mor­tal­i­ty, child­hood under­nu­tri­tion, and adult­hood chron­ic dis­ease. OBJECTIVES: The spe­cif­ic aims of this study were to esti­mate the asso­ci­a­tion between short mater­nal stature and out­comes of…

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Patient-to-nurse ratios and outcomes of moderately preterm infants.

Prof­it et al, Pedi­atrics. 2010 Feb; Abstract OBJECTIVE: Mod­er­ate­ly preterm infants (30–34(6/7) weeks’ ges­ta­tion­al age) rep­re­sent the largest pop­u­la­tion of NICU res­i­dents. Whether their clin­i­cal out­comes are asso­ci­at­ed with dif­fer­ences in NICU nurse-staffing arrange­ments has not been assessed. The objec­tive of this study was to test the influ­ence of patient-to-nurse…

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