Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns

Terrin et al, Pediatrics, 2012 Gastric acidity is a major nonimmune defense mechanism against infections. The objective of this study was to investigate whether ranitidine treatment in very low birth weight (VLBW) infants is associated with an increased risk of infections, necrotizing enterocolitis (NEC), and fatal outcome. RESULTS: We evaluated 274 VLBW…

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Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants

Smit et al, 2013, Cochrane neonatology group Intraventricular haemorrhage (IVH) is a major complication of preterm birth. Large haemorrhages are associated with a high risk of disability and hydrocephalus. Instability of blood pressure and cerebral blood flow are postulated as causative factors. Another mechanism may involve reperfusion damage from oxygen…

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A propensity-matched cohort study of vancomycin-associated nephrotoxicity in neonates

Constance et al, Arch Dis Child Fetal Neonatal Ed. 2015 Sep 23.  BACKGROUND: The incidence of nephrotoxicity among vancomycin-treated neonates has been reported to range from 2% to 20%. These widely varying estimates have led to confusion and controversy regarding the safety of vancomycin among neonates. OBJECTIVE: Evaluate the incidence of nephrotoxicity among neonates receiving vancomycin concomitantly…

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Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates

Cochrane review, 18 February 2015 Background Establishment of secure airway is a critical part of neonatal resuscitation both in the delivery room and in the neonatal unit. Videolaryngoscopy is a new technique that has the potential to facilitate successful endotracheal intubation and decrease adverse consequences of delay in airway stabilization.…

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Variation in Prenatal Diagnosis of Congenital Heart Disease in Infants

 Quartermain, et al Pediatrics, 2015 .  ABSTRACT BACKGROUND AND OBJECTIVE: Prenatal diagnosis allows improved perioperative outcomes for fetuses with certain forms of congenital heart disease (CHD). Variability in prenatal diagnosis has been demonstrated in other countries, leading to efforts to improve fetal imaging protocols and access to care, but has…

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