A Randomized Trial of Phototherapy with Filtered Sunlight in African Neonates

Slush­er, et al, N Engl J Med 2015 BACKGROUND Seque­lae of severe neona­tal hyper­biliru­bine­mia con­sti­tute a sub­stan­tial dis­ease bur­den in areas where effec­tive con­ven­tion­al pho­tother­a­py is unavail­able. We pre­vi­ous­ly found that the use of fil­tered sun­light for the pur­pose of pho­tother­a­py is a safe and effi­ca­cious method for reduc­ing total biliru­bin. How­ev­er,…

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Mental performance in 8-year-old children fed reduced protein content formula during the 1st year of life: safety analysis of a randomised clinical trial.

Escrib­ano et al, Br J Nutr. 2016 Jan In humans, max­i­mum brain devel­op­ment occurs between the third trimester of ges­ta­tion and 2 years of life. Nutri­tion dur­ing these crit­i­cal win­dows of rapid brain devel­op­ment might be essen­tial for lat­er cog­ni­tive func­tion­ing and behav­iour. In the last few years, trends on pro­tein rec­om­men­da­tions dur­ing infan­cy…

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Azithromycin in early infancy and pyloric stenosis

Eber­ly et al, Pedi­atrics. 2015 March Abstract BACKGROUND AND OBJECTIVE: Use of oral ery­thromycin in infants is asso­ci­at­ed with infan­tile hyper­trophic pyloric steno­sis (IHPS). The risk with azithromycin remains unknown. We eval­u­at­ed the asso­ci­a­tion between expo­sure to oral azithromycin and ery­thromycin and sub­se­quent devel­op­ment of IHPS. CONCLUSIONS: Inges­tion of oral azithromycin and ery­thromycin places young infants at increased…

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Long-term effects of caffeine therapy for apnea of prematurity on sleep at school age

Mar­cus et al ‚Am J Respir Crit Care Med. 2014 Oct Abstract RATIONALE: Apnea of pre­ma­tu­ri­ty is a com­mon con­di­tion that is usu­al­ly treat­ed with caf­feine, an adeno­sine recep­tor block­er that has pow­er­ful influ­ences on the cen­tral ner­vous sys­tem. How­ev­er, lit­tle is known about the long-term effects of caf­feine on sleep in the devel­op­ing brain. OBJECTIVES:…

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Angiotensin-converting enzyme inhibitor nephrotoxicity in neonates with cardiac disease

Lin­dle KA, et al, Pedi­atr Car­di­ol. 2014 March Abstract Angiotensin-con­vert­ing enzyme inhibitors (ACEi) are com­mon­ly used for pedi­atric car­di­ol­o­gy patients. How­ev­er, stud­ies exam­in­ing their safe­ty for neonates with car­diac dis­ease are scarce. The cur­rent study aimed to test the hypoth­e­sis that ACEi-medi­at­ed nephro­tox­i­c­i­ty occurs in neonates and may be under­ap­pre­ci­at­ed in this pop­u­la­tion.…

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Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full-term infants.

Yahia et al, Eur J Pedi­atr. 2015 Apr Abstract Con­cerns of pos­si­ble geno­tox­ic effects of hyper­biliru­bine­mia and pho­tother­a­py were raised from exper­i­men­tal and obser­va­tion­al stud­ies in neonates. This study aimed to assess the impact of hyper­biliru­bine­mia and pho­tother­a­py on DNA dam­age and apop­to­sis in periph­er­al blood lym­pho­cytes in healthy full-term infants.…

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Jaundice, phototherapy and DNA damage in full-term neonates.

Ramy et al, J Peri­na­tol. 2016 Feb Abstract OBJECTIVE: Pho­tother­a­py is the stan­dard ther­a­peu­tic approach for neona­tal hyper­biliru­bine­mia. Oxida­tive effects of pho­tother­a­py may have poten­tial harms, includ­ing DNA dam­age. Uncon­ju­gat­ed biliru­bin (UCB) might also pos­sess antigeno­tox­ic poten­tial. Inten­sive pho­tother­a­py is more effi­ca­cious than con­ven­tion­al pho­tother­a­py in treat­ing hyper­biliru­bine­mia. This study aimed…

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Apnea of Prematurity.

AAP Issues Guid­ance on Apnea of Pre­ma­tu­ri­ty. Pedi­atrics, Jan­u­ary 2016, Eric C. Eichen­wald, COMMITTEE ON FETUS AND NEWBORN, From the Amer­i­can Acad­e­my of Pedi­atrics, Clin­i­cal Report Abstract   Apnea of pre­ma­tu­ri­ty is one of the most com­mon diag­noses in the NICU. Despite the fre­quen­cy of apnea of pre­ma­tu­ri­ty, it is unknown whether recur­rent apnea, brady­car­dia, and…

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Neonatal glucocorticoid treatment: long-term effects on the hypothalamus-pituitary-adrenal axis, immune system, and problem behavior in 14–17 year old adolescents

Ter Wol­beek et al, Brain Behav Immun. 2015 Mar Neona­tal glu­co­cor­ti­coid (GC) treat­ment is used to pre­vent bron­chopul­monary dys­pla­sia (BPD) in pre­ma­ture­ly born babies. In the 1990s, treat­ment reg­i­mens with rel­a­tive­ly high dos­es of dex­am­etha­sone (DEX) were com­mon. As an alter­na­tive, hydro­cor­ti­sone (HC) was used. Ear­li­er, we com­pared long-term effects of both GCs in chil­dren aged 7–10…

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Fetal antiepileptic drug exposure: Adaptive and emotional/behavioral functioning at age 6years

Cohen et al, Epilep­sy Behav. 2013 Nov The Neu­rode­vel­op­men­tal Effects of Antiepilep­tic Drugs (NEAD) study is a prospec­tive obser­va­tion­al mul­ti­cen­ter study in the USA and UK, which enrolled preg­nant women with epilep­sy on antiepilep­tic drug (AED) monother­a­py from 1999 to 2004. The study aimed to deter­mine if dif­fer­en­tial long-term neu­rode­vel­op­men­tal effects exist…

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