PortSaid Neonatology Group

Mater­nal vit­a­min D defi­cien­cy in ear­ly preg­nan­cy is asso­ci­at­ed with an increased risk of behav­ioral issues and atten­tion-deficit/hy­per­ac­tiv­i­ty dis­or­der (ADHD)–like symp­toms in preschool chil­dren, accord­ing to new data from a birth cohort study in Greece. But no asso­ci­a­tion was found between mater­nal vit­a­min D defi­cien­cy and cog­ni­tive scores in the…

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Duffy et al, Pedi­atrics, June 2016 Abstract BACKGROUND AND OBJECTIVE: An increased risk of febrile seizure (FS) was iden­ti­fied with con­comi­tant admin­is­tra­tion of triva­lent inac­ti­vat­ed influen­za vac­cine (IIV3) and pneu­mo­coc­cal con­ju­gate vac­cine (PCV) 13-valent dur­ing the 2010–2011 influen­za sea­son. Our objec­tive was to deter­mine whether con­comi­tant admin­is­tra­tion of IIV3 with oth­er vac­cines…

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Wood et al, Acad Pedi­atr.  2016  OBJECTIVE: To deter­mine range of bot­tle sizes used and exam­ine the rela­tion­ship between bot­tle size and total dai­ly con­sump­tion of infant for­mu­la. RESULTS: Of 865 par­tic­i­pants in the Green­light study, 44% of infants were exclu­sive­ly for­mu­la fed at 2 months. Medi­an vol­ume per day…

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Maim­burg et al, Epilep­sy Res. 2016 May 19 Abstract:  PURPOSE: The aim of the study was to esti­mate the asso­ci­a­tion between new­born chil­dren treat­ed with pho­toter­apy for hyper­biliru­bine­mia and the sub­se­quent risk of febrile seizures or epilep­sy in ear­ly child­hood. METHODS: We con­duct­ed a fol­low-up study of sin­gle­ton chil­dren (N=70 230) born between Feb­ru­ary…

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MacLean et al, Tho­rax. 2016 Jun 3.  Abstract BACKGROUND: Extreme preterm birth con­fers risk of long-term impair­ments in lung func­tion and exer­cise capac­i­ty. There are lim­it­ed data on the fac­tors con­tribut­ing to exer­cise lim­i­ta­tion fol­low­ing extreme preterm birth. This study exam­ined res­pi­ra­to­ry mechan­ics and ven­ti­la­to­ry response dur­ing exer­cise in a large cohort of…

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Sher­man et al, J Pedi­atr. 2016 May 31. Abstract OBJECTIVE:To eval­u­ate the safe­ty and explore the effi­ca­cy of recom­bi­nant human lacto­fer­rin (talacto­fer­rin [TLf]) to reduce infec­tion. STUDY DESIGN: a ran­dom­ized, dou­ble blind, place­bo-con­trolled tri­al in infants with birth weight of 750‑1500 g.  RESULTS: The rate of hos­pi­tal-acquired infec­tions was 50% low­er in the…

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Gkentzi et al, Curr Pedi­atr Rev. 2016 Jun 3 Depart­ment of Pae­di­atrics, Uni­ver­si­ty Gen­er­al Hos­pi­tal of Patras, Patras Med­ical School, Rio, Greece Abstract BACKGROUND: Coag­u­lase-neg­a­tive staphy­lo­coc­ci (CoNS) are the lead­ing cause of late-onset sep­sis in neona­tal inten­sive-care units (NICUs). Despite ade­quate ther­a­peu­tic lev­els and in vivo sus­cep­ti­bil­i­ty, van­comycin is not always ade­quate…

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Improved sur­vival rates in pre­ma­ture infants and more sen­si­tive neu­roimag­ing tech­niques have expand­ed the scope of rec­og­nized neu­rode­vel­op­men­tal dis­abil­i­ties in this vul­ner­a­ble pop­u­la­tion and have impli­cat­ed a role for cere­bel­lar pathol­o­gy in their ori­gin. Although supra­ten­to­r­i­al patholo­gies are well stud­ied, cere­bel­lar pathol­o­gy has been under-rec­og­nized in pre­ma­ture infants. The pur­pose…

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Takeuchi et al, Brain Dev. 2016 May 10 Abstract OBJECTIVE: To inves­ti­gate the preva­lence of and the peri­na­tal risk fac­tors relat­ed to read­ing dif­fi­cul­ty in school-aged very low birth weight infants (VLBWI) with nor­mal intel­li­gence. RESULTS: Twen­ty-five (31.6%) out of 79 sub­jects had RD. We dis­cov­ered that treat­ed retinopa­thy of pre­ma­tu­ri­ty (tRoP) was…

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Nataluc­ci et al, JAMA. 2016 May 17 Abstract IMPORTANCE: Very preterm infants are at risk of devel­op­ing encephalopa­thy of pre­ma­tu­ri­ty and long-term neu­rode­vel­op­men­tal delay. Ery­thro­poi­etin treat­ment is neu­ro­pro­tec­tive in ani­mal exper­i­men­tal and human clin­i­cal stud­ies. OBJECTIVE: To deter­mine whether pro­phy­lac­tic ear­ly high-dose recom­bi­nant human ery­thro­poi­etin (rhE­PO) in preterm infants improves neu­rode­vel­op­men­tal out­come at…

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Pee­len et al, Acta Obstet Gynecol Scand. 2016 May 24 Abstract INTRODUCTION: Fetal gen­der is asso­ci­at­ed with preterm birth, how­ev­er a prop­er sub­di­vi­sion by onset of labor and cor­re­spond­ing neona­tal out­come by week of ges­ta­tion is lack­ing. RESULTS:The study pop­u­la­tion com­prised 1 736 615 sin­gle­ton deliv­er­ies (25+0 -42+6 weeks). Male fetus­es were…

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Szpecht et al, Childs Nerv Syst. 2016 May 28 Abstract INTRODUCTION: Intra­ven­tric­u­lar hem­or­rhage (IVH) affects 15–20 % of babies born before 32 weeks of preg­nan­cy. A lot of risk fac­tors of devel­op­ing IVH are known. The mak­ing appro­pri­ate rec­om­men­da­tions for deal­ing with infant born less than 32 weeks of ges­ta­tion aimed at reduc­ing the inci­dence…

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Olgun et al, Pedi­atr Neona­tol. 2016 Apr 29. Abstract BACKGROUND: There are lim­it­ed data about the results of repeat­ed oral ibupro­fen (OIBU) treat­ment. This study aimed to describe patent duc­tus arte­rio­sus (PDA) clo­sure rates and adverse events after repeat­ed cours­es of OIBU in pre­ma­ture infants with PDA. METHODS: Preterm infants with hemo­dy­nam­i­cal­ly sig­nif­i­cant…

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Hit­tner et al, Oph­thal­mol­o­gy. 2016 May Abstract PURPOSE: To deter­mine inci­dence, risk fac­tors, risk peri­od, and char­ac­ter­is­tics of recur­rent retinopa­thy of pre­ma­tu­ri­ty (ROP) treat­ed by intrav­it­re­al beva­cizum­ab (IVB) monother­a­py. RESULTS: Intrav­it­re­al beva­cizum­ab monother­a­py in 241 infants (471 eyes) was reviewed. Recur­rence inci­dence was 8.3% (20/241) for infants and 7.2% (34/471) for eyes.  CONCLUSIONS: Pre­ma­ture…

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Rodriguez et al, J Matern Fetal Neona­tal Med. 2016 May Abstract OBJECTIVE: Com­pare the oral col­o­niza­tion pro­file of pre­ma­ture infants admit­ted at NICU before and after doing oral care rou­tine with ster­ile water ver­sus no inter­ven­tion. METHODS: It was a ran­dom­ized clin­i­cal tri­al com­posed of 37 pre­ma­ture infants admit­ted at the NICU RESULT: In the…

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Derien­zo, et al,  Ear­ly Hum Dev. 2014 May Abstract AIMS: The objec­tive of this study is to deter­mine the inci­dence of and risk fac­tors for necro­tiz­ing ente­ro­col­i­tis (NEC) and trans­fu­sion-asso­ci­at­ed NEC (TANEC) in very-low-birth-weight (VLBW) infants pre/post imple­men­ta­tion of a peri-trans­fu­sion feed­ing pro­to­col. RESULTS: A total of 148/1380 (10.7%) infants devel­oped…

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Chris­tensen, et al  Pedi­atrics, july 2015 BACKGROUND: Throm­bo­cy­tope­nia is com­mon among small-for-ges­ta­tion­al-age (SGA) neonates (birth weight <10th per­centile ref­er­ence range), but sev­er­al aspects of this throm­bo­cy­tope­nia are unclear, includ­ing the inci­dence, typ­i­cal nadir, dura­tion, asso­ci­a­tion with preeclamp­sia, mech­a­nism, and risk of death. METHODS: Using 9 years of mul­ti­hos­pi­tal records, wes­t­ud­ied SGA neonates…

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Ras­to­gi et al, Int J Pedi­atr Otorhi­no­laryn­gol. 2013 Mar Abstract INTRODUCTION:There is increased risk of hear­ing loss in preterm neonates. This risk is fur­ther increased by envi­ron­men­tal noise expo­sure espe­cial­ly from life sup­port equip­ment such as ven­ti­la­tion. Nasal con­tin­u­ous pos­i­tive air­way pres­sure (NCPAP) used for res­pi­ra­to­ry sup­port of preterm neonates is known…

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Härkin et al, J Pedi­atr. 2016 May Abstract OBJECTIVE: To study the bio­log­ic effect of parac­eta­mol, an inhibitor of prostaglandin syn­thase, on ear­ly clo­sure of duc­tus arte­rio­sus, and to eval­u­ate pos­si­ble adverse effects asso­ci­at­ed with the drug. RESULTS: Of 63 screened infants, 48 were ran­dom­ized: 23 were assigned to parac­eta­mol and 25 to…

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Pam­mi & Abrams, Cochrane Data­base Syst Rev. 2015 Feb Abstract BACKGROUND: Lacto­fer­rin, a nor­mal com­po­nent of human colostrum and milk, can enhance host defense and may be effec­tive in the pre­ven­tion of sep­sis and necro­tiz­ing ente­ro­col­i­tis (NEC) in preterm neonates. OBJECTIVES: Pri­ma­ry objec­tive To assess the safe­ty and effec­tive­ness of oral lacto­fer­rin in the…

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Kent et al, Nutri­ents. 2015 Feb Abstract Human milk is recog­nised as the best form of nutri­tion for infants. How­ev­er; in instances where breast-feed­ing is not pos­si­ble, unsuit­able or inad­e­quate, infant milk for­mu­lae are used as breast milk sub­sti­tutes. These for­mu­lae are designed to pro­vide infants with opti­mum nutri­tion for nor­mal…

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Wick­re­mas­inghe, et al, Pedi­atrics 2016 OBJECTIVE: To deter­mine whether neona­tal pho­tother­a­py is asso­ci­at­ed with can­cer in the first abstract year after birth. RESULTS: Can­cer was diag­nosed in 58/178 017 infants with diag­no­sis codes for pho­tother­a­py and 1042/4 966 832 infants with­out such codes (32.6/100 000 vs 21.0/100 000; rel­a­tive risk 1.6; 95% con­fi­dence inter­val [CI],…

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Holmes et al, Pedi­atrics, 2016 Abstract BACKGROUND AND OBJECTIVE: The inci­dence and asso­ci­at­ed costs of neona­tal absti­nence syn­drome (NAS) have recent­ly risen sharply; new­borns with NAS occu­py 4% of NICU beds. We imple­ment­ed a coor­di­nat­ed pro­gram for NAS includ­ing stan­dard­ized pro­to­cols for scor­ing, med­ica­tions and wean­ing, and a calm room­ing-in…

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Lam et al, Neona­tol­ogy, 2014 Abstract BACKGROUND: Infants receiv­ing pro­longed par­enter­al nutri­tion (PN) are at risk of PN-asso­ci­at­ed cholesta­sis (PNAC). This can progress to hepat­ic fail­ure and death if PN can­not be dis­con­tin­ued. Fish oil-based par­enter­al lipid prepa­ra­tion (FOLP) has been shown to be ben­e­fi­cial in case stud­ies. OBJECTIVES: (1)…

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