Antenatal manifestations of inborn errors of metabolism: biological diagnosis

Saban et al, J Inher­it Metab Dis. 2016 Jul 8 Abstract Inborn errors of metab­o­lism (IEMs) that present with abnor­mal imag­ing find­ings in the sec­ond half of preg­nan­cy are main­ly lyso­so­mal stor­age dis­or­ders (LSDs), cho­les­terol syn­the­sis dis­or­ders (CSDs), glyco­gen stor­age dis­or­der type IV (GSD IV), per­ox­i­so­mal dis­or­ders, mito­chon­dr­i­al fat­ty acid oxi­da­tion…

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A Systematic Review of the Uterine Relaxant Effect of Herbal Sources

Reza­eizadeh G et al, Curr Pharm Biotech­nol. 2016 Jun 30. Abstract BACKGROUND:   Preterm birth is a world­wide tragedy with a high inci­dence. Sev­er­al med­ica­tions are used to inhib­it acute preterm labor, but tocol­y­sis by these med­i­cines do not extend preg­nan­cy beyond 1–2 days. OBJECTIVES: The pur­pose of this study was to dis­cov­er…

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Effect of olive oil massage on weight gain in preterm infants: A randomized controlled clinical trial

Jabraeile et al, Niger Med J. 2016 May-Jun;57 Abstract BACKGROUND: Despite the fact that effect of mas­sage with or with­out oil on the baby’s weight gain is not clear, but recent stud­ies have shown that mas­sage with essen­tial oils make lipid absorp­tion through the skin. The aim of this study was to eval­u­ate…

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Benign pneumoperitoneum in newborns: which abdomen to open and which one to observe?

Al-Lawa­ma, et al, Clin Case Rep. 2016 May Abstract Benign pneu­moperi­toneum in new­borns is not a rare con­di­tion that should be man­aged con­ser­v­a­tive­ly. Neona­tol­o­gists and sur­gi­cal teams should work togeth­er to avoid unnec­es­sary and poten­tial­ly risky pro­ce­dures. Read the Full arti­cle from the fol­low­ing link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891479/

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Contrast Enema and Risk of Sepsis in Premature Babies: A 12-Year Retrospective Study

Agar­w­al et al, Am J Peri­na­tol. 2016 Jul 11 Abstract Objec­tive: The objec­tive of this study was to inves­ti­gate the asso­ci­a­tion between con­trast ene­ma (CE) and clin­i­cal sep­sis (CS) in pre­ma­ture babies (PB) and the role of antibi­otics (ABs) in its pre­ven­tion. Study Design: A ret­ro­spec­tive elec­tron­ic chart review of preterm babies, who…

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Apnea after Routine Eye Examinations in Premature Infants

Reid et al, Am J Peri­na­tol. 2016 Jul 11. Abstract Objec­tive: To deter­mine the fre­quen­cy of car­diores­pi­ra­to­ry events fol­low­ing rou­tine exams for retinopa­thy of pre­ma­tu­ri­ty (ROP). Results: Approx­i­mate­ly 19 to 25% of infants expe­ri­enced an increase in car­diores­pi­ra­to­ry events in the 24 hours fol­low­ing their eye exams. These new­borns were gen­er­al­ly of a…

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Neonatal thyroid-stimulating hormone concentration and psychomotor development at preschool age

 Trumpff  et al, Arch Dis Child. 2016 Jul 8. Abstract OBJECTIVE: Thy­roid hor­mones are essen­tial for nor­mal brain devel­op­ment. The aim of this study is to assess if high con­cen­tra­tion of thy­roid stim­u­lat­ing hor­mone (TSH) that is below the clin­i­cal thresh­old (5–15 mIU/L) at neona­tal screen­ing is linked to psy­chomo­tor devel­op­ment impair­ments in…

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Neonatal intensive care unit lighting: update and recommendations

Rodríguez & Pat­ti­ni, Arch Argent Pedi­atr. 2016 Aug Abstract Achiev­ing ade­quate light­ing in neona­tal inten­sive care units is a major chal­lenge: in addi­tion to the usu­al con­sid­er­a­tions of visu­al per­for­mance, cost, ener­gy and aes­thet­ics, there appear dif­fer­ent bio­log­i­cal needs of patients, health care providers and fam­i­ly mem­bers. Com­mu­ni­ca­tion­al aspects of light, its…

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Cardiopulmonary resuscitation in hospitalized infants

Hornik et al, Ear­ly Hum Dev. 2016 Jul 8 Abstract BACKGROUND: Hos­pi­tal­ized infants requir­ing car­diopul­monary resus­ci­ta­tion (CPR) rep­re­sent a high-risk group. Recent data on risk fac­tors for mor­tal­i­ty fol­low­ing CPR in this pop­u­la­tion are lack­ing. STUDY DESIGN: Ret­ro­spec­tive cohort study. RESULTS: The cohort con­sist­ed of 2231 infants receiv­ing CPR. Of these, 1127 (51%) sur­vived to…

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Abnormal vaginal colonization by gram-negative bacteria is significantly higher in pregnancy conceived through infertility treatment compared to natural pregnancy.

Kim et al, J Matern Fetal Neona­tal Med. 2016 May Abstract OBJECTIVE: To com­pare abnor­mal vagi­nal col­o­niza­tion between nat­ur­al preg­nan­cy and preg­nan­cy by infer­til­i­ty treat­ment in high-risk par­turi­ent women and to exam­ine the asso­ci­a­tion between abnor­mal vagi­nal col­o­niza­tion and ear­ly-onset neona­talsep­sis (EONS). RESULTS: Among 1096 preg­nan­cies, the rate of vagi­nal col­o­niza­tion by gram-neg­a­tive bac­te­ria, espe­cial­ly Escherichia coli was…

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Neonatal outcomes according to different therapies for gestational diabetes mellitus.

Sil­va et al, J Pedi­atr (Rio J). 2016 Jun 28 Abstract OBJECTIVES: To com­pare dif­fer­ent neona­tal out­comes accord­ing to the dif­fer­ent types of treat­ments used in the man­age­ment of ges­ta­tion­al dia­betes mel­li­tus (GDM). METHODS: This was a ret­ro­spec­tive cohort study. The study pop­u­la­tion com­prised preg­nant women with GDM treat­ed at a pub­lic mater­ni­ty…

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Serum Lactate Levels and Perfusion index: Are These Prognostic Factors on Mortality and Morbidity in Very Low Birth Weight Infants?

Tuten et al, J Matern Fetal Neona­tal Med. 2016 Jun Abstract AIM: Ear­ly hemo­dy­nam­ic assess­ment of glob­al para­me­ters in crit­i­cal­ly ill new­borns fails and requires most­ly inva­sive mea­sure­ments in neona­tal inten­sive care unit. Clin­i­cal signs are fre­quent­ly used for assess­ment of periph­er­al per­fu­sion. Per­fu­sion index (PI) is a new non­in­va­sive numer­i­cal val­ue…

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Higher or lower oxygen for delivery room resuscitation of preterm infants below 28 completed weeks gestation: a meta-analysis

Oei et al, Arch Dis Child Fetal Neona­tal, May 2016 Abstract Objec­tive: To sys­tem­at­i­cal­ly review out­comes of infants ≤28+6 weeks ges­ta­tion ran­domised to resus­ci­ta­tion with low (≤0.3) vs high (≥0.6) frac­tion of inspired oxy­gen (FiO2) at deliv­ery. Design: Sys­tem­at­ic review of ran­domised con­trolled tri­als of low (≤0.3) vs high (≥0.6) FiO2resuscitation.  Main out­come mea­sures:…

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Glycerin Suppositories Use in Very Low Birth Weight Infants.

Patel et al, Am J Peri­na­tol. 2016 Jul 1 Abstract Objec­tive: To study the char­ac­ter­is­tics of very low birth weight (VLBW) infants receiv­ing glyc­erin sup­pos­i­to­ries (GS) and eval­u­ate the asso­ci­a­tion of GS use with out­comes.   Results: A total of 1,073 infants were includ­ed in the study. Out of those, 527 (49.1%) infants…

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Impact of hands-on care on infant sleep in the neonatal intensive care unit.

Levy  et al, Pedi­atr Pul­monol. 2016 Jun 30 Abstract STUDY OBJECTIVES: Sleep dis­rup­tion is increas­ing­ly rec­og­nized in hos­pi­tal­ized patients. Impaired sleep is asso­ci­at­ed with mea­sure­able alter­ations in neu­rode­vel­op­ment. The neona­tal inten­sive care unit (NICU) envi­ron­ment has the poten­tial to affect sleep qual­i­ty and quan­ti­ty. We aimed: (i) to deter­mine the fre­quen­cy and…

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Risk Factors for Extubation Failure in Extremely Low Birth Weight Infants.

Wang et al, Pedi­atr Neona­tol. 2016 Jun 7. Abstract BACKGROUND: Although ante­na­tal steroids and ear­ly use nasal con­tin­u­ous pos­i­tive air­way pres­sure (NCPAP) have sig­nif­i­cant­ly improved out­comes of neona­tal res­pi­ra­to­ry dis­tress syn­drome, intu­ba­tion with ven­ti­la­tor sup­port is still com­mon­ly required in extreme­ly low birth weight (ELBW) infants. The opti­mal tim­ing of extu­ba­tion in…

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Duration and intensity of fluconazole for prophylaxis in preterm neonates

A meta-analy­sis of ran­dom­ized con­trolled tri­als. Che et al, BMC Infect Dis. 2016 Jun 27 Abstract BACKGROUND: The cur­rent­ly avail­able evi­dence shows flu­cona­zole is an effec­tive pro­phy­lax­is treat­ment against inva­sive fun­gal infec­tions in preterm neonates in neona­tal inten­sive care units (NICUs). How­ev­er, the dura­tion and dos­ing of this pro­phy­lax­is treat­ment remain con­tro­ver­sial. Thus,…

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What is a normal blood glucose?

Güemes et al,  Arch Dis Child 2016 Review Abstract Glu­cose is the key meta­bol­ic sub­strate for tis­sue ener­gy pro­duc­tion. In the peri­na­tal peri­od the moth­er sup­plies glu­cose to the fetus and for most of the ges­ta­tion­al peri­od the nor­mal low­er lim­it of fetal glu­cose con­cen­tra­tion is around 3 mmol/L. Just after…

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Maternal serotonin transporter genotype affects risk for ASD with exposure to prenatal stress.

Hecht et al, Autism Res. 2016 Apr Abstract Stress expo­sure dur­ing ges­ta­tion is impli­cat­ed in sev­er­al neu­ropsy­chi­atric con­di­tions, includ­ing autism spec­trum dis­or­der (ASD). Pre­vi­ous research showed that pre­na­tal stress increas­es risk for ASD with peak expo­sure dur­ing the end of the sec­ond and the begin­ning of the third trimester. How­ev­er, expo­sures…

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Prenatal Cannabis and Tobacco Exposure in Relation to Brain Morphology

A Prospec­tive Neu­roimag­ing Study in Young Chil­dren El Mar­roun et al, Biol Psy­chi­a­try. 2016 Jun Abstract BACKGROUND: Cannabis use dur­ing preg­nan­cy has been asso­ci­at­ed with neg­a­tive behav­ioral out­comes and psy­chopathol­o­gy in off­spring. How­ev­er, there has been lit­tle research eval­u­at­ing alter­ations in brain struc­ture as a result of mater­nal cannabis use. In this…

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Neonatal resuscitation equipment: A hidden risk for our babies?

Winck­worth et al, J Pae­di­a­tr Child Health. 2016 May Abstract AIM: Neona­tal infec­tions car­ry a heavy bur­den of mor­bid­i­ty and mor­tal­i­ty. Poor prac­tice can result in unin­ten­tion­al coloni­sa­tion of med­ical equip­ment with poten­tial­ly path­o­gen­ic organ­isms. This study will deter­mine the preva­lence and type of bac­te­r­i­al con­t­a­m­i­na­tion on exposed­neona­tal resus­ci­ta­tion equip­ment in…

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Mortality due to Respiratory Syncytial Virus: Burden and Risk Factors

Geoghe­gan et al, Am J Respir Crit Care Med. 2016 Abstract RATIONALE: Res­pi­ra­to­ry syn­cy­tial virus (RSV) is the most fre­quent cause of hos­pi­tal­iza­tion and an impor­tant cause of death in infants in the devel­op­ing world. The rel­a­tive con­tri­bu­tion of social, bio­log­i­cal, and clin­i­cal risk fac­tors to RSV mor­tal­i­ty in low-income regions is…

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Assisted Reproductive Technology and Birth Defects

Assist­ed Repro­duc­tive Tech­nol­o­gy and Birth Defects Among Live­born Infants in Flori­da, Mass­a­chu­setts, and Michi­gan, 2000–2010 Boulet et al, JAMA Pedi­atr. 2016 Impor­tance  Use of assist­ed repro­duc­tive tech­nol­o­gy (ART) has been asso­ci­at­ed with increased risks for birth defects. Vari­a­tions in birth defect risks accord­ing to type of ART pro­ce­dure have been not­ed,…

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Vancomycin toxicity in neonates: a review of the evidence

Lest­ner et al, Curr Opin Infect Dis. 2016 Jun Abstract PURPOSE OF REVIEW: Van­comycin is a first-line agent in the treat­ment of seri­ous Gram-pos­i­tive infec­tions in the neona­tal pop­u­la­tion. The pub­lished evi­dence on van­comycin tox­i­c­i­ty in neonates is lim­it­ed. This review sum­ma­rizes pre­clin­i­cal stud­ies and clin­i­cal tri­als describ­ing van­comycin tox­i­c­i­ty. We dis­cuss pro­posed…

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